Polydrug Dependence

We Do Recover

Polydrug dependence occurs when an individual becomes reliant on two or more drugs simultaneously, often leading to complex and hazardous health effects. For instance, someone might be dependent on both alcohol and benzodiazepines, a combination that significantly increases the risk of severe respiratory depression and overdose. Another example is the dependence on both opioids and stimulants, such as heroin and cocaine, which can lead to erratic behavior and heightened strain on the cardiovascular system. This form of dependence complicates treatment and recovery, as it involves addressing the effects and withdrawal symptoms of multiple substances, each with its unique challenges and health risks.

Polydrug dependence refers to the practice of mixing drugs or taking one drug while under the influence of another, which significantly increases the risks and dangers. The more substances a person consumes simultaneously, the greater the likelihood of adverse effects. The effects of polydrug use vary depending on the drugs combined and are influenced by several factors, including the drug’s purity, amount, frequency of use, the user’s mood, expectations, personality, and the environment where the drugs are used. Using multiple drugs at once makes the effects more unpredictable, especially when combining drugs with similar physical effects, like multiple stimulants or depressants, which can amplify their impact on brain and body functions.

Many people who develop polydrug dependence start by using one substance and then progress to using multiple substances to achieve a specific effect. The combination of different drugs can lead to cycle that can be difficult to break and that can have dire consequences.

Polydrug dependence has been observed throughout history such as the use of alcohol and opium together was a widespread and regular occurence. When combined with alcohol, cocaine produces a psychoactive metabolite called cocaethylene, which is more toxic to the cardiovascular and hepatic systems than cocaine itself and has a longer elimination half-life.

There is a long-standing issue of polydrug dependence in society. The treatment of polydrug dependence is complex and challenging for addiction recovery professionals. The wide range of substances involved makes it essential for rehab programs that require specilised medical care that understands the compounds and their effects in the detoxification process and the individual.

    Addiction and Mental Health

    Treatment Services

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    Founded in 2008, WeDoRecover has evolved from an advisory service for addiction treatment into a comprehensive provider of care, following its 2019 merger with Changes Addiction Rehab in Johannesburg. Specializing in connecting patients to top-tier addiction treatment centers in the UK, South Africa, and Thailand, WeDoRecover supports individuals globally, including those from the United Arab Emirates and Europe. Accepting both South African medical aid and international health insurance, the organization facilitates access to high-quality treatment for substance and alcohol use disorders, offering individualized care that addresses the physical, mental, and social needs of patients.

    Our team, led by Gareth Carter, offers empathetic and professional support, guiding you through every step of the treatment process. Whether you're in South Africa or abroad, our acceptance of various insurance plans makes quality care accessible, providing a platform for lasting recovery and a healthier future.

    Inpatient Rehab

    Our rehab care is a good option if you are at risk of experiencing strong withdrawal symptoms when you try stop a substance. This rehab option would also be recommended if you have experienced recurrent relapses or if you have tried a less-intensive treatment without success.


    If you're committed to your sobriety but cannot take a break from your daily duties for an inpatient program. Outpatient rehab treatment might suit you well if you are looking for a less restricted format for addiction treatment or simply need help with mental health.


    Therapy can be good step towards healing and self-discovery. If you need support without disrupting your routine, therapy offers a flexible solution for anyone wishing to enhance their mental well-being or work through personal issues in a supportive, confidential environment.

    Mental Health

    Are you having persistent feelings of being swamped, sad or have sudden surges of anger or intense emotional outbursts? These are warning signs of unresolved trauma mental health. A simple assesment by a mental health expert could provide valuable insights into your recovery.

    Finding the right rehab close to you is simple with WeDoRecover. Our network includes the finest rehab centers, ensuring personalised, quality care for your recovery needs. Let Gareth Carter and our empathetic team help guide you to a center that feels right for you, offering expert care and support. Start your healing today by choosing a rehab that's not just close to you, but also that truly cares about your loved ones recovery.

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