Reversed Tolerance

We Do Recover

Reverse tolerance, or drug sensitization, is a pharmacological concept where repeated use of a drug leads to increased reactions, either positive or negative, which is contrary to traditional drug tolerance where effects decrease with repeated use. Notably, reverse tolerance doesn’t apply to all drugs. In the context of alcohol use, heavy drinkers may initially develop tolerance, requiring more alcohol to achieve the desired effect. However, excessive drinking can lead to liver damage, making them more susceptible to intoxication with even small amounts of alcohol. Sensitization particularly occurs with the euphoric effects of alcohol but not with its physical effects like sedation, which lessen over time. This phenomenon doesn’t happen with substances like benzodiazepines, where only a diminishing effect is observed with repeated use.

Reverse tolerance is also observed in stimulant users, such as those using cocaine or amphetamines. In these cases, doses that were once recreational can lead to severe reactions like psychosis, especially in regular users or those with a history of psychotic episodes. Furthermore, reverse tolerance implies that lower doses can trigger such reactions in future uses.

Additionally, the term ‘drug sensitization’ can refer to medical strategies aimed at reducing tolerance developed from prolonged drug use, such as implementing a drug holiday. This aspect highlights the complex nature of drug tolerance and sensitization, reinforceing the importance of understanding these concepts in substance use and addiction management.

    Addiction and Mental Health

    Treatment Services

    Founded in 2008, WeDoRecover has evolved from an advisory service for addiction treatment into a comprehensive provider of care, following its 2019 merger with Changes Addiction Rehab in Johannesburg. Specializing in connecting patients to top-tier addiction treatment centers in the UK, South Africa, and Thailand, WeDoRecover supports individuals globally, including those from the United Arab Emirates and Europe. Accepting both South African medical aid and international health insurance, the organization facilitates access to high-quality treatment for substance and alcohol use disorders, offering individualized care that addresses the physical, mental, and social needs of patients.

    Our team, led by Gareth Carter, offers empathetic and professional support, guiding you through every step of the treatment process. Whether you're in South Africa or abroad, our acceptance of various insurance plans makes quality care accessible, providing a platform for lasting recovery and a healthier future.

    Inpatient Rehab

    Our rehab care is a good option if you are at risk of experiencing strong withdrawal symptoms when you try stop a substance. This rehab option would also be recommended if you have experienced recurrent relapses or if you have tried a less-intensive treatment without success.


    If you're committed to your sobriety but cannot take a break from your daily duties for an inpatient program. Outpatient rehab treatment might suit you well if you are looking for a less restricted format for addiction treatment or simply need help with mental health.


    Therapy can be good step towards healing and self-discovery. If you need support without disrupting your routine, therapy offers a flexible solution for anyone wishing to enhance their mental well-being or work through personal issues in a supportive, confidential environment.

    Mental Health

    Are you having persistent feelings of being swamped, sad or have sudden surges of anger or intense emotional outbursts? These are warning signs of unresolved trauma mental health. A simple assesment by a mental health expert could provide valuable insights into your recovery.

    Finding the right rehab close to you is simple with WeDoRecover. Our network includes the finest rehab centers, ensuring personalised, quality care for your recovery needs. Let Gareth Carter and our empathetic team help guide you to a center that feels right for you, offering expert care and support. Start your healing today by choosing a rehab that's not just close to you, but also that truly cares about your loved ones recovery.

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